Respond with strengths that correspond with qualities the employer is looking for. Use a part of the job opening that you lack experience in and use that as a weakness (i.e.: “I haven’t used this type of system but I am a quick study.”) Take a weakness from long ago and explain how you overcame it. Don’t shoot yourself in the foot by bearing your soul to the interviewer. Have a couple examples of each in case the question asks for a list of strengths/weaknesses.